Methanesulfonyl chloride mesyl chloride is an organosulfur compound with the formula ch3so2cl. The reaction mixture was stirred at 0 c for 30 min, then was allowed to warm to rt over 2 h. Reacts explosively with dimethyl sulfoxide buckley, a. Methanesulfonyl chloride mesyl chloride is a compound containing asulfonyl chloride used to make methanesulfonates and to generate sulfene. Methanesulfonyl chloride 124630 msds report, methanesulfonyl chloride msds safety technical specifications search, methanesulfonyl chloride safety information specifications ect. Predicted data is generated using the us environmental protection agencys episuite. Methanesulfonyl chloride 124630 msds, safety technical. The combined organics were washed with h2o 20 ml, brine 20 ml, dried. Methanesulfonyl chloride msc1 is a versatile reagent that can be used to introduce mesyl groups ch3so22 via. The mechanism of action of this compound includes the potentiation of glucose uptake demonstrated in 3t3l1 adipocytes as well as the stimulation. Als environmental provides no warranty, expressed or implied, as to the accuracy, reliability or completeness of furnished data. Information for methanesulfonyl chloride 124630 including methanesulfonyl chloride cas no 124630, methanesulfonyl chloride suppliers, methanesulfonyl chloride manufacturers, related products of methanesulfonyl chloride.
Methanesulfonyl chloride mesyl chloride is an organosulfur compound with the formula ch 3 so 2 cl. Chemical compatibility chart the attached information has been prepared in good faith by rapra technology limited and other sources. About 14% of these are dyestuff intermediates, % are chloride, and 54% are pharmaceutical intermediates. The reaction of methanesulfonyl chloride with alcohols in.
Groups of five male and five female spraguedawley rats were exposed to methanesulfonyl chloride at 0, 20, 28, or 54 ppm analytic concentrations for 4 h, followed by a 14day observation period pennwalt corporation 1987. The mixture was quenched with h2o 10 ml and extracted with dcm 2 x 20 ml. Sds of methanesulfonyl chloride, safety data sheets, cas 124630. Information should be used as a guide only, as the information is only current at the date of publication. Mscl is the compound obtained when the hydroxy group in the molecule of methanesulfonic acid is replaced with a chlorine atom. Additional information 96hr lc50 guppy static with neutralized msc. Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Methanesulfonyl chloride is mainly used to give methanesulfonates by its reaction with alcohols in the presence of a nonnucleophilic base. Methane is transformed selectively to methanesulfonyl chloride at low temperature by liquidphase reaction of methane with so 2cl 2 in the presence of a free radical initiator and a promoter using 100% h 2so 4 as the solvent.
In the case of contact with eyes, rinse immediately with plenty of water and seek medical. Methanesulfonyl chloride is a precursor to many compounds because it is highly reactive. Harmful to aquatic life with long lasting effects hazardous to the aquatic. Information provided on methanesulfonyl chloride 124630 is for reference only and is subject to change. Use this link for bookmarking this species for future reference. Methanesulfonyl chloride can be used as catalyst, chlorinating agent, firming agent, stabilizer or as an intermediate for dyes, pharmaceuticals and pesticides. Find msds or sds, a coa, data sheets and more information. Perchloric acid, sodium salt in aqueous solution, sp product code. Sciencemadness discussion board methanesulfonic acid. Als environmental does not sell chemicals, but offers analytical lab testing to determine the presence of various elements and chemical compounds. Methanesulfonyl chloride supplier distributor cas 124630. Thionyl chloride is on the hazardous substance list because. Burning sodium perchlorate may produce chlorine, chlorine dioxide, hydrogen chloride, and oxides of nitrogen as well as mixtures with any other compounds involved in the combustion. Methanesulfonyl chloride reacts vigorously with water, steam, alkali, methylformamide.
A single example of a secondary alcohol produced the chloride in 50% yield. Wholebody exposure chambers were constructed of perspex and had an internal volume of 115 l. Safety data sheet methanesulfonyl chloride date prepared. After stirring for 2 hours, gas evolution ceases, and a clear, colorless solution of sodium methanesulfinate note 3 is obtained. There is no warranty of accuracy or completeness of any information contained herein. A typical synthesis is to treat methanesulfonyl chloride with potassium fluoride or potassium bifluoride in water and then steam distill the product out. Sep 11, 2014 register now and get a free online msds binder. Methanesulfonyl chloride prices,suppliers methanesulfonyl. It is a colourless liquid that dissolves in polar organic solvents but is reactive toward water, alcohols, and many amines.
Reach registration 172120042741640000 sds compliant with regulations. Methanesulfonyl chloride using the organic pseudoelement symbol ms for the methanesulfonyl or mesyl group ch3so2, it is frequently abbreviated mscl in reaction schemes or equations. Ungraded products supplied by spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use. Methanesulfonyl chloride information about methanesulfonyl chloride is for educational purposes only. There are a wide variety of direct reading instruments and analytical sampling. Methanesulfonyl chloride is the reagent used to convert alcohols into alkyl mesylates. Methanesulfonyl chloride, also known as mesyl chloride, can be used to generate the elusive molecule sulfene and to make methanesulfonates. Mesyl chloride, methyl sulfonyl chloride cas number 124630. Methanesulfonyl chloride vaillancourt major reference works. These methanesulfonyl chloride manufacturing companies are delivering best quality products to the clients on time. Methanesulfonyl chloride msds material safety data sheet or sds, coa and coq, dossiers.
Applicationsmethanesulfonates the main use of methanesulfonyl chloride is the formation of methanesulfonates from alcohols in the presence of a. Column type active phase temperature c i reference comment. Development and validation of a gcms with sim method for the. Methanesulfonyl chloride, methanesulfonyl chloride supplier, methanesulfonyl chloride distributor, cas 124630, methanesulfonyl chloride manufacturer, methanesulfonyl chloride wholesale. In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Show this safety data sheet to the doctor in attendance. Using the organic pseudoelement symbol ms for the methanesulfonyl or mesyl group ch 3 so 2, it is frequently abbreviated mscl in reaction schemes or equations. These are common byproducts of combustion and are likely to be serious health concern. Methanesulfonyl chloride an overview sciencedirect topics.
Ac125640000, ac125640010, ac125640050, ac12564, ac125642500 synonyms. Buy methanesulfonyl chloride d3,c cas 1216581019, a biochemical for proteomics research, from santa cruz. Methanesulfonic acid chloridecas no124630molecular formula. Cas 124630, ec number 2047061, chemical formula ch. Methanesulfonyl chlorided 3 was obtained in 52% yield, and a small amount of dimethyl sulfoned 6 was also isolated. Methanesulfonyl chloride ch3clo2s cid 31297 structure, chemical names, physical and. It is a colourless liquid that dissolves in polar organic solvents but is. This does not prevent hcl formation by a catalytic mechanism, but under normal conditions methanesulfonyl chloride is quite unreactive argonne report anldis001, october 2000. Sds of methanesulfonyl chloride, safety data sheets, cas. Emergency preparedness and response safety and health. Sultams obtained as a mixture of two isomers are separable by silica gel column. One reagent lane fair lawn, nj 07410 for information in north america. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. Citation data is made available by participants in crossrefs citedby linking service.
Buy methanesulfonyl chlorided3,c cas 1216581019, a biochemical for proteomics research, from santa cruz. One reagent lane fair lawn, nj 07410 for information in north america, call. Als environmental is a laboratory testing network and is not affiliated with the u. After stirring for 2 hours, gas evolution ceases, and a clear, colorless solution of. Sigmaaldrich offers a number of methanesulfonyl chloride products. Methylene chloride please ensure that this msds is given to, and explained to people using this product. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Trichloromethyl methyl sulfide d 3 was found to be one of the intermediates in this reaction. Alcohol to mesylate methanesulfonyl chloride meso2cl. Methanesulfonyl chloride or mesyl chloride abbreviation. Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. It undergoes decomposition on heating to liberate additional toxic fumes of fluorides and sulfur oxides so x.
In case of more serious fires, also alcoholresistant foam and water spray. Methanesulfonyl chloride cas 124630 msds guidechem. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Synthesis of methanesulfonyl chloride msc from methane and. Under the authority of the federal advisory committee act faca p. Listing here the database of methanesulfonyl chloride cas no 124630, methanesulfonyl chloride manufacturers, suppliers and exporters. Articles of methanesulfonyl chloride are included as well. Methanesulfonyl chloride cas no 124630 manufacturers. Synthesis of methanesulfonyl chloride msc from methane. For a more comprehensive list of citations to this article, users are encouraged to perform a search inscifinder the reaction of 23sydnonylphenylmethanol with sulfonyl chlorides. Better yields are obtained using a t butylimine 83% than an aryl imine 1859% equation 14. The slightly exothermic reaction is accompanied by the evolution of carbon dioxide. Experimental work at argonne national laboratory has determined that there is essentially no hcl gas formation.
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